20mg/mL 5.5mL CAS 1191237-69-0 GS441524 GS For FIP Treatment
Product Description
GS-441524 is a nucleoside analogue antiviral drug which became advanced with the aid of using Gilead Sciences. It is the primary plasma metabolite of the antiviral prodrug remdesivir, and has a half-existence of round 24 hours in human patients. Remdesivir and GS-441524 had been each located to be powerful in vitro in opposition to tom cat coronavirus traces liable for tom cat infectious peritonitis (FIP), a deadly systemic ailment affecting home cats. Remdesivir became in no way examined in cats (aleven though a few vets now provide it[1]), however GS-441524 has been located to be powerful remedy for FIP and is extensively used regardless of no authentic FDA approval because of Gilead's refusal to license this drug for veterinary use.
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Appearance |
Transparent liquid, powder or tablets |
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GS Standard |
99.5%min |
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Size |
5.5 ml/ Vial |
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Content |
15mg/ml or 20mg/ml |
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Application |
For CAT FIP R&D Use ONLY |
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Wet FIP |
6-7 mg/kg |
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Dry FIP |
7-8 mg/kg |
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Ocular or Neuro FIP |
8 mg/kg |
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Increased ocular/neuro |
9 mg/kg |
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Max ocular/neuro |
10 mg/kg |
What is FIP?
Neurogenic Feline Infectious Peritonitis (FIP) is a serious disease in cats caused by mutations in the common feline intestinal (gut) coronavirus (FeCoV). The mutation allows the otherwise trivial virus to enter intestinal macrophages (a type of immune system cell) and hitch a ride to other parts of the body, infecting the abdominal cavity, chest cavity, eyes and certain parts of the gastrointestinal tract to escape the lining of the gastrointestinal tract. Example, the brain. Normally, the feline immune system prevents clinical FIP, but in some cats infected with intestinal FeCoV, the immune system is unable to eliminate the infection and the development of clinical FIP can have devastating consequences.
Over 30% of pet cats and over 80% of breeding cats have been exposed to FeCoV (the relatively harmless intestinal form).
While the relatively harmless enteric coronavirus (FeCoV) is highly transmissible among cats, the mutated form of FIP itself does not infect other cats, and feline coronaviruses are different from the human coronaviruses that cause COVID-19.
Clinical symptoms of FIP
Cats with clinical FIP will show a range of clinical signs, such as:
(1) Fever not responding to antibiotics
(2) Fluid in the abdominal and/or chest cavity
(3) Palpable swollen lymph nodes in the abdomen
(4) Symmetrical changes in pupil or eye color
(5) Neurological signs (brain infection)
Clinical signs depend on whether the cat has an exudative or "wet" form of FIP or a non-exudative or "dry" form of FIP, although there is often a combination of wet and dry forms known as "mixed wet and dry" FIP.
Dry FIP is often more difficult to diagnose because there is no apparent fluid-filled body cavity to sample, but rather a focal (eg, bowel or kidney) or multiple site (eg, abdominal cavity, brain) pus granuloma formation.
Cats at risk of FIP
The majority of cats that develop FIP affected are young between 3 months and 2 years of age (80%), or elderly cats, and the disease often affects purebred cats, especially the following breeds: Ragdolls, Abyssinians, Bengals, British Short Hairs, Exotics, Devon Rex, Birmans.
Interesting, the purebreds that are less commonly represented are Siamese, Persian and Himalayan cats.
Cats that have been housed together in a rescue facility where multiple cats share a litter tray are also at a higher risk of developing FIP.
FIP is more common in male cats, with a male to female ratio of 2:1.
Any cat that has previously been exposed to enteric feline coronavirus can potentially develop FIP, but in the vast majority of cats, the enteric coronavirus is insignificant and does not require any treatment.
FAQ
Q: What is GS441?
A: GS is short for GS which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field .
It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please checking with Julia for the details!
Q: How long is the treatment?
A: Recommended treatment based on Niche Petcare is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat's symptoms should be assessed to see if additional treatment is needed.
Q: What is the correct dose of GS441 to give my kitty?
A: Dosing is based on the weight of the cat.
If you love math, the formula to calculate is:
5mg*(GS) x weight(kg) / GS concentration per 1mL**=dose per 24hr
*Neurological and Ocular FIP cats require 8mg/kg MINIMUM.
Can go as high as 10mg/kg for extreme ocular or neurological cases.
*GS concentration per 1ml = total GS in bottle (mg) / total solution volume (mL)
Q: What exactly are "neuro" or "ocular" cases?
A: "Neuro" cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected
Q: What size syringes and needles do I need?
A: Depending on what your cat's dose is, you can used either a 1 mL or a 3 mL syringe. Use a 20 gauge needle to draw up the GS into the syringe and then it's best to CHANGE the needle to a fresh one of the same size OR SLIGHTLY SMALLER (21 or 22 gauge) to inject. The GS liquid is somewhat thick and a larger needle allows it to be drawn up and injected faster. The LENGTH of needle can be anywhere from 1/2" to 1 1/2" in length. It's a bit of a personal preference. Some usethe longer needles to try and avoid any GS leaking out, some are more comfortable injecting with a shorter needle. You DEFINITELY want Luer-lock needles so they can be secured to the syringes and not pop off.
A NOTE ON NEEDLE GAUGE SIZES: The number used to describe the circumference or "width" of the needle opening gets larger as the size of the opening gets smaller. For example, an 18 gauge needle has a larger opening than a 21 gauge needle.
Q: How do I give the GS441 injections?
A: The injections are given sub-cutaneously or "sub-cu" which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It's best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet.
Q: What are the side effects of GS441?
A: The only known side effects of GS are pain during injections and the possibility of skin lesions forming at the injection sites.
Q: My kitty is on GS and now has diarrhea. What should I do?
A: We recommend giving B-12, bland food and a probiotic. Pumpkin puree is also okay to give. Fortiflora or Proviable are two probiotics. If the cat seems to be getting dehydrated, giving sub-cutaneous fluids is okay
Q: How long after completing FIP treatment should I wait to spay/neuter my cat?
A: 3 months.
