Feline Infectious Peritonitis (FIP) 20mg/mL 5.5mL GS441524 PIF
Product Description
GS-441524 is a nucleoside analogue antiviral drug which became advanced with the aid of using Gilead Sciences. It is the primary plasma metabolite of the antiviral prodrug remdesivir, and has a half-existence of round 24 hours in human patients. Remdesivir and GS-441524 had been each located to be powerful in vitro in opposition to tom cat coronavirus traces liable for tom cat infectious peritonitis (FIP), a deadly systemic ailment affecting home cats. Remdesivir became in no way examined in cats (aleven though a few vets now provide it), however GS-441524 has been located to be powerful remedy for FIP and is extensively used regardless of no authentic FDA approval because of Gilead's refusal to license this drug for veterinary use.
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Appearance |
Transparent liquid, powder or tablets |
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GS Standard |
99.5%min |
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Size |
5.5 ml/ Vial |
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Content |
15mg/ml or 20mg/ml |
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Application |
For CAT FIP R&D Use ONLY |
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Wet FIP |
6-7 mg/kg |
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Dry FIP |
7-8 mg/kg |
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Ocular or Neuro FIP |
8 mg/kg |
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Increased ocular/neuro |
9 mg/kg |
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Max ocular/neuro |
10 mg/kg |
What is FIP?
Nervous feline infectious peritonitis (FIP) is a serious disease caused by the mutation of common intestinal coronavirus (FeCoV) in cats. This mutation makes the originally insignificant virus enter the intestinal macrophages (an immune system cell) and hitchhike to other parts of the body, infecting the abdominal cavity, chest cavity, eyes, and in some cases the brain, thus entering the gastrointestinal tract. Usually, the immune system of cats will prevent clinical FIP, but in some cats infected with FeCoV, the immune system cannot eliminate the infection, and clinical FIP will have devastating consequences.
Although the relatively harmless intestinal coronavirus (FeCoV) is highly transmitted among cats, the mutant FIP itself will not infect other cats. Cat coronavirus is different from the human coronavirus that causes 2019 coronavirus disease.
Clinical signs of FIP
Cats with clinical FIP will have a series of clinical symptoms, such as:
-Fever unresponsive to antibiotics
-Peritoneal and / or pleural effusion
-Palpable abdominal lymphadenopathy
-Changes in pupil symmetry or eye color
-Neurological symptoms (brain infection)
FAQ
Q: What is GS441?
A: GS is short for GS which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field .
It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please checking with Julia for the details!
Q: How long is the treatment?
A: Recommended treatment based on Niche Petcare is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat's symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are "neuro" or "ocular" cases?
A: "Neuro" cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected
Q: How do I give the GS441 injections?
A: The injections are given sub-cutaneously or "sub-cu" which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It's best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet.
Q: What are the side effects of GS441?
A: The only known side effects of GS are pain during injections and the possibility of skin lesions forming at the injection sites.
Q: Should I continue to use flea/tick treatment for my FIP kitty during treatment?
A: No. Do not use Revolution, Frontline or other chemical flea/tick treatments while on FIP treatment. The biggest part of treating for fleas is the environment. Vacuum daily (floors, closets, bedding, anything the cats come in contact with) and wash all bedding. You can flea comb your cat daily to remove fleas. You can make a mixture of water and apple cider vinegar (2:1) to apply on a cloth and wipe onto your cat daily so the fleas don't want to be on her. Revolution is one of the moresafe options, but I would hesitate to combine it with GS for fear of affecting the GS being able to have full effect.
Q: How long after completing FIP treatment should I wait to spay/neuter my cat?
A: 3 months.
