FIP Treatment GS 441 GS Treatment for FIP In Cats CAS 1191237-69-0
Product Description
|
Appearance |
Transparent liquid, powder or tablets |
|
GS Standard |
99.5%min |
|
Size |
5.5 ml/ Vial |
|
Content |
15mg/ml or 20mg/ml |
|
Application |
For CAT FIP R&D Use ONLY |
|
Wet FIP |
6-7 mg/kg |
|
Dry FIP |
7-8 mg/kg |
|
Ocular or Neuro FIP |
8 mg/kg |
|
Increased ocular/neuro |
9 mg/kg |
|
Max ocular/neuro |
10 mg/kg |
What is FIP?
Neurogenic Feline Infectious Peritonitis (FIP) is a serious disease in cats caused by mutations in the common feline intestinal (gut) coronavirus (FeCoV). The mutation allows the otherwise trivial virus to enter intestinal macrophages (a type of immune system cell) and hitch a ride to other parts of the body, infecting the abdominal cavity, chest cavity, eyes and certain parts of the gastrointestinal tract to escape the lining of the gastrointestinal tract. Example, the brain. Normally, the feline immune system prevents clinical FIP, but in some cats infected with intestinal FeCoV, the immune system is unable to eliminate the infection and the development of clinical FIP can have devastating consequences.
Over 30% of pet cats and over 80% of breeding cats have been exposed to FeCoV (the relatively harmless intestinal form).
While the relatively harmless enteric coronavirus (FeCoV) is highly transmissible among cats, the mutated form of FIP itself does not infect other cats, and feline coronaviruses are different from the human coronaviruses that cause COVID-19.
Clinical symptoms of FIP
Cats with clinical FIP will show a range of clinical signs, such as:
(1) Fever not responding to antibiotics
(2) Fluid in the abdominal and/or chest cavity
(3) Palpable swollen lymph nodes in the abdomen
(4) Symmetrical changes in pupil or eye color
(5) Neurological signs (brain infection)
Clinical signs depend on whether the cat has an exudative or "wet" form of FIP or a non-exudative or "dry" form of FIP, although there is often a combination of wet and dry forms known as "mixed wet and dry" FIP.
Dry FIP is often more difficult to diagnose because there is no apparent fluid-filled body cavity to sample, but rather a focal (eg, bowel or kidney) or multiple site (eg, abdominal cavity, brain) pus granuloma formation.
Use and research
Since FIP is commonly deadly and there aren't anyt any permitted remedies available, GS-441524 has reportedly been offered at the black marketplace and utilized by puppy proprietors to deal with affected cats, despite the fact that Gilead Sciences has refused to license the drug for veterinary use. Its efficacy for this cause has been conclusively proven in more than one trials, together with discipline trials,or even in greater complex sorts of FIP together with people with multisystemic or neurological involvement.
FAQ
Q: What is GS441?
A: GS is short for GS which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field .
It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please checking with Julia for the details!
Q: How long is the treatment?
A: Recommended treatment based on Niche Petcare is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat's symptoms should be assessed to see if additional treatment is needed.
Q: What is the correct dose of GS441 to give my kitty?
A: Dosing is based on the weight of the cat.
If you love math, the formula to calculate is:
5mg*(GS) x weight(kg) / GS concentration per 1mL**=dose per 24hr
*Neurological and Ocular FIP cats require 8mg/kg MINIMUM.
Can go as high as 10mg/kg for extreme ocular or neurological cases.
*GS concentration per 1ml = total GS in bottle (mg) / total solution volume (mL)
Q: What exactly are "neuro" or "ocular" cases?
A: "Neuro" cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected
Q: How do I give the GS441 injections?
A: The injections are given sub-cutaneously or "sub-cu" which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It's best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet.
Q: Should I continue to use flea/tick treatment for my FIP kitty during treatment?
A: No. Do not use Revolution, Frontline or other chemical flea/tick treatments while on FIP treatment. The biggest part of treating for fleas is the environment. Vacuum daily (floors, closets, bedding, anything the cats come in contact with) and wash all bedding. You can flea comb your cat daily to remove fleas. You can make a mixture of water and apple cider vinegar (2:1) to apply on a cloth and wipe onto your cat daily so the fleas don't want to be on her. Revolution is one of the moresafe options, but I would hesitate to combine it with GS for fear of affecting the GS being able to have full effect.
Q: How long after completing FIP treatment should I wait to spay/neuter my cat?
A: 3 months.
